Caspase 8 antibody (AA 217-374) (HRP)

Catalog No. ABIN7146967

This anti-Caspase 8 antibody is a Rabbit Polyclonal antibody detecting Caspase 8 in ELISA. Suitable for Human.

Quick Overview for Caspase 8 antibody (AA 217-374) (HRP) (ABIN7146967)

Target: Caspase 8 (CASP8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 8 antibody is conjugated to HRP

Application: ELISA

Product Details anti-Caspase 8 Antibody (HRP)

Binding Specificity: AA 217-374

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Caspase-8 protein (217-374AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Caspase 8

Target: Caspase 8 (CASP8)

Alternative Name: CASP8

Background:

Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Aliases: ALPS2B antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody, Apoptosis related cysteine peptidase antibody, Apoptotic cysteine protease antibody, Apoptotic protease Mch-5 antibody, Apoptotic protease Mch5 antibody, CAP 4 antibody, CAP4 antibody, CASP-8 antibody, CASP8 antibody, CASP8_HUMAN antibody, Caspase 8 antibody, Caspase 8 apoptosis related cysteine peptidase antibody, Caspase IIX antibody, Caspase-8 subunit p10 antibody, caspase8 antibody, CED 3 antibody, FADD Homologous ICE/CED3 Like Protease antibody, FADD Like ICE antibody, FADD-homologous ICE/CED-3-like protease antibody, FADD-like ICE antibody, FLICE antibody, FLJ17672 antibody, ICE-like apoptotic protease 5 antibody, MACH alpha 1/2/3 protein antibody, MACH antibody, MACH beta 1/2/3/4 protein antibody, MACH5 antibody, MCH 5 antibody, MCH5 antibody, MGC78473 antibody, MORT1 associated ced 3 homolog antibody, MORT1 associated CED3 homolog antibody, MORT1-associated CED-3 homolog antibody, OTTHUMP00000163717 antibody, OTTHUMP00000163720 antibody, OTTHUMP00000163724 antibody, OTTHUMP00000163725 antibody, OTTHUMP00000165062 antibody, OTTHUMP00000165063 antibody, OTTHUMP00000165064 antibody, OTTHUMP00000206552 antibody, OTTHUMP00000206582 antibody

UniProt: Q14790

Pathways: Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades