Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO) (AA 184-302) antibody (Biotin)

Catalog No. ABIN7147838

Product Details

Target: Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO)

Binding Specificity: AA 184-302

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Aryl Hydrocarbon Receptor Nuclear Translocator Homolog (TGO)

Alternative Name: BHLHE4

Background:

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

Aliases: BHE40_HUMAN antibody, bHLHB2 antibody, bHLHe40 antibody, Class B Basic Helix Loop Helix Protein 2 antibody, Class B basic helix-loop-helix protein 2 antibody, Class E basic helix loop helix protein 40 antibody, Class E basic helix-loop-helix protein 40 antibody, Clast5 antibody, DEC1 antibody, Differentially expressed in chondrocytes protein 1 antibody, E47 interaction protein 1 antibody, EIP1 antibody, Enhancer of split and hairy related protein 2 antibody, Enhancer-of-split and hairy-related protein 2 antibody, SHARP 2 antibody, SHARP-2 antibody, Stimulated by retinoic acid gene 13 protein antibody, STRA13 antibody

UniProt: O14503