Cytosolic Arginine Sensor For mTORC1 Subunit 2 (CASTOR2) (AA 82-329) antibody (HRP)

Catalog No. ABIN7149382

Product Details

Target: Cytosolic Arginine Sensor For mTORC1 Subunit 2 (CASTOR2)

Binding Specificity: AA 82-329

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Cytosolic Arginine Sensor For mTORC1 Subunit 2 (CASTOR2)

Alternative Name: CASTOR2

Background:

Background: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Aliases: CASTOR2 antibody, Cellular arginine sensor for mTORC1 protein 2 antibody, GATL2_HUMAN antibody, GATS-like protein 2 antibody, GATSL2 antibody

UniProt: A6NHX0