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Topoisomerase I antibody (AA 358-501) (HRP)

TOP1 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7374385
  • Target See all Topoisomerase I (TOP1) Antibodies
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Binding Specificity
    • 11
    • 11
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 358-501
    Reactivity
    • 64
    • 25
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 10
    • 2
    Rabbit
    Clonality
    • 45
    • 19
    Polyclonal
    Conjugate
    • 34
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Topoisomerase I antibody is conjugated to HRP
    Application
    • 40
    • 21
    • 17
    • 13
    • 8
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA topoisomerase 1 protein (358-501AA)
    Isotype
    IgG
    Top Product
    Discover our top product TOP1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Alternative Name
    TOP1 (TOP1 Products)
    Synonyms
    CG6146 antibody, Dmel\\CG6146 antibody, TOP1 antibody, TopI antibody, Topo I antibody, TopoI antibody, dTopoI antibody, l(1)G0134 antibody, l(1)G0201 antibody, l(1)G0229 antibody, l(1)G0278 antibody, l(1)top1 antibody, top1 antibody, topo I antibody, topoI antibody, DNA topoisomerase 1 beta antibody, DNA topoisomerase I alpha antibody, MGO1 antibody, MGOUN 1 antibody, MTE17.1 antibody, MTE17_1 antibody, TOP1BETA antibody, TOPOISOMERASE 1 antibody, TOPI antibody, AI467334 antibody, D130064I21Rik antibody, Top-1 antibody, Ab2-086 antibody, topi antibody, Topoisomerase 1 antibody, DNA topoisomerase I antibody, DNA topoisomerase I alpha antibody, DNA topoisomerase 1 antibody, topoisomerase (DNA) I antibody, DNA topoisomerase I, gene 1 L homeolog antibody, Top1 antibody, top1 antibody, topA antibody, ZMO1193 antibody, MRAD2831_RS63095 antibody, Lferr_0016 antibody, PC1_2015 antibody, Za10_0136 antibody, Gbro_0575 antibody, Dd586_2108 antibody, Kvar_3044 antibody, Alvin_2069 antibody, Dacet_0849 antibody, Mrub_1615 antibody, Arnit_2962 antibody, Ndas_4953 antibody, Trad_2377 antibody, Acear_1653 antibody, Mahau_0844 antibody, Mesop_4109 antibody, Thein_1586 antibody, Theth_0241 antibody, TOP1ALPHA antibody, top-1 antibody, TOP1 antibody, top1.1.L antibody
    Target Type
    Viral Protein
    Background

    Background: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3\'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5\'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5\'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

    Aliases: DNA topoisomerase 1 antibody, DNA topoisomerase I antibody, NUP98 fusion gene antibody, TOP 1 antibody, TOP I antibody, TOP1 antibody, TOP1_HUMAN antibody, TOPI antibody, Topoisomerase (DNA) I antibody, Topoisomerase 1 antibody, Topoisomerase1 antibody, TopoisomeraseI antibody, Type I DNA topoisomerase antibody

    UniProt
    P11387
    Pathways
    Caspase Cascade in Apoptosis, Stem Cell Maintenance
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