EIF2S3 antibody (AA 173-472)

Catalog No. ABIN7152135

Product Details anti-EIF2S3 Antibody

Target: EIF2S3 (Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa (EIF2S3))

Binding Specificity: AA 173-472

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2S3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Eukaryotic translation initiation factor 2 subunit 3 protein (173-472AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EIF2S3

Target: EIF2S3 (Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa (EIF2S3))

Alternative Name: EIF2S3 (EIF2S3 Products)

Synonyms: EIF2 antibody, EIF2G antibody, EIF2gamma antibody, eIF-2gA antibody, Su(var)3-9 antibody, fi03g03 antibody, wu:fi03g03 antibody, wu:fi37d04 antibody, zgc:63805 antibody, EIF2S3 antibody, eif2 antibody, eif2g antibody, eif2s3y antibody, eif2gamma antibody, Eif2g antibody, Eif2s3 antibody, PP42 antibody, ENSMUSG00000079297 antibody, eukaryotic translation initiation factor 2 subunit gamma antibody, eukaryotic translation initiation factor 2, subunit 3 gamma antibody, eukaryotic translation initiation factor 2 subunit gamma S homeolog antibody, putative eukaryotic translation initiation factor 2 subunit 3-like protein antibody, eukaryotic translation initiation factor 2 subunit 3 antibody, predicted pseudogene 2223 antibody, EIF2S3 antibody, eif2s3 antibody, eif2s3.S antibody, LOC738402 antibody, LOC100179499 antibody, LOC100624149 antibody, Eif2s3 antibody, Gm2223 antibody

Background:

Background: As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Aliases: eIF-2-gamma X antibody, eIF-2gA antibody, eIF-2gX antibody, EIF2 antibody, EIF2G antibody, EIF2gamma antibody, EIF2S3 antibody, Eukaryotic translation initiation factor 2 gamma antibody, Eukaryotic translation initiation factor 2 gamma subunit antibody, Eukaryotic translation initiation factor 2 subunit 3 antibody, Eukaryotic translation initiation factor 2 subunit 3 gamma 52 kDa antibody, Eukaryotic translation initiation factor 2 subunit gamma X antibody, IF2G_HUMAN antibody

UniProt: P41091