WDR24 antibody (AA 1-298) (HRP)
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- Target See all WDR24 products
- WDR24 (WD Repeat Domain 24 (WDR24))
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Binding Specificity
- AA 1-298
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WDR24 antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human GATOR complex protein WDR24 protein (1-298AA)
- Isotype
- IgG
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- WDR24 (WD Repeat Domain 24 (WDR24))
- Alternative Name
- WDR24 (WDR24 Products)
- Synonyms
- C16orf21 antibody, JFP7 antibody, BC037651 antibody, wu:fd05f12 antibody, zgc:55946 antibody, WD repeat domain 24 antibody, WD repeat domain 24 L homeolog antibody, WDR24 antibody, Wdr24 antibody, wdr24 antibody, wdr24.L antibody
- Background
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Background: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
Aliases: C16orf21 antibody, DKFZp434F054 antibody, JFP7 antibody, LA16c-313D11.2 antibody, WD repeat-containing protein 24 antibody, wdr24 antibody, WDR24_HUMAN antibody
- UniProt
- Q96S15
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