PAI1 antibody (AA 24-398)

Catalog No. ABIN7163532

The Rabbit Polyclonal anti-PAI1 antibody has been validated for WB, IHC, ELISA and IF. It is suitable to detect PAI1 in samples from Human.

Quick Overview for PAI1 antibody (AA 24-398) (ABIN7163532)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-PAI1 Antibody

Binding Specificity: AA 24-398

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: SERPINE1

Background:

Background: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).

Aliases: Clade E antibody, Endothelial plasminogen activator inhibitor antibody, Nexin antibody, Nexin plasminogen activator inhibitor type 1 antibody, PAI 1 antibody, PAI antibody, PAI-1 antibody, PAI1_HUMAN antibody, PLANH1 antibody, Plasminogen activator inhibitor 1 antibody, Plasminogen activator inhibitor type 1 antibody, Serine (or cysteine) proteinase inhibitor antibody, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody, Serine proteinase inhibitor clade E member 1 antibody, serpin antibody, Serpin E1 antibody, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody, Serpin peptidase inhibitor clade E antibody, Serpine 1 antibody, SERPINE1 antibody

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration