POU4F1 antibody (AA 258-419) (HRP)
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- Target See all POU4F1 Antibodies
- POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))
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Binding Specificity
- AA 258-419
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POU4F1 antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human POU domain, class 4, transcription factor 1 protein (258-419AA)
- Isotype
- IgG
- Top Product
- Discover our top product POU4F1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))
- Alternative Name
- POU4F1 (POU4F1 Products)
- Synonyms
- BRN3A antibody, Oct-T1 antibody, RDC-1 antibody, brn-3A antibody, POU4F1 antibody, Brn-3a antibody, Brn-3 antibody, Brn-3.0 antibody, Brn3 antibody, Brn3.0 antibody, Brn3a antibody, E130119J07Rik antibody, brn3.0 antibody, brn3a antibody, brn3a-A antibody, oct-t1 antibody, rdc-1 antibody, POU class 4 homeobox 1 antibody, POU domain, class 4, transcription factor 1 antibody, POU class 4 homeobox 1 L homeolog antibody, POU4F1 antibody, Pou4f1 antibody, pou4f1 antibody, Tsp_01181 antibody, pou4f1.L antibody
- Background
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Background: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5\'-ATGCAAAT-3\' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.
Aliases: Brain specific homeobox/POU domain protein 3A antibody, Brain-3A antibody, Brain-specific homeobox/POU domain protein 3A antibody, Brn 3.0 antibody, BRN 3A antibody, Brn-3A antibody, Brn3 antibody, BRN3A antibody, class 4 antibody, FLJ13449 antibody, Homeobox/POU domain protein RDC 1 antibody, Homeobox/POU domain protein RDC-1 antibody, Homeobox/POU domain protein RDC1 antibody, Oct T1 antibody, Oct-T1 antibody, OctT1 antibody, PO4F1_HUMAN antibody, POU class 4 homeobox 1 antibody, POU domain antibody, POU Domain Class 4 Transcription Factor 1 antibody, Pou4f1 antibody, RDC 1 antibody, RDC1 antibody, transcription factor 1 antibody
- UniProt
- Q01851
- Pathways
- Feeding Behaviour
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