RUNX2 antibody (AA 219-404)

Catalog No. ABIN7168485

The Rabbit Polyclonal anti-RUNX2 antibody has been validated for WB and ELISA. It is suitable to detect RUNX2 in samples from Human.

Quick Overview for RUNX2 antibody (AA 219-404) (ABIN7168485)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RUNX2 Antibody

Binding Specificity: AA 219-404

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Runt-related transcription factor 2 protein (219-404AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2

Background:

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5\'-PYGPYGGT-3\', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

Aliases: Acute myeloid leukemia 3 protein antibody, Alpha subunit 1 antibody, AML3 antibody, CBF alpha 1 antibody, CBF-alpha-1 antibody, CBFA1 antibody, CCD antibody, CCD1 antibody, Cleidocranial dysplasia 1 antibody, Core binding factor antibody, Core binding factor runt domain alpha subunit 1 antibody, Core binding factor subunit alpha 1 antibody, Core-binding factor subunit alpha-1 antibody, MGC120022 antibody, MGC120023 antibody, Oncogene AML 3 antibody, Oncogene AML-3 antibody, OSF 2 antibody, OSF-2 antibody, OSF2 antibody, Osteoblast specific transcription factor 2 antibody, Osteoblast-specific transcription factor 2 antibody, OTTHUMP00000016533 antibody, PEA2 alpha A antibody, PEA2-alpha A antibody, PEA2aA antibody, PEBP2 alpha A antibody, PEBP2-alpha A antibody, PEBP2A1 antibody, PEBP2A2 antibody, PEBP2aA antibody, PEBP2aA1 antibody, Polyomavirus enhancer binding protein 2 alpha A subunit antibody, Polyomavirus enhancer-binding protein 2 alpha A subunit antibody, Runt domain antibody, Runt related transcription factor 2 antibody, Runt-related transcription factor 2 antibody, RUNX2 antibody, RUNX2_HUMAN antibody, SL3 3 enhancer factor 1 alpha A subunit antibody, SL3-3 enhancer factor 1 alpha A subunit antibody, SL3/AKV core binding factor alpha A subunit antibody, SL3/AKV core-binding factor alpha A subunit antibody

UniProt: Q13950