SMARCC1 antibody (AA 80-320)

Catalog No. ABIN7171052

Product Details anti-SMARCC1 Antibody

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Binding Specificity: AA 80-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human SWI/SNF complex subunit SMARCC1 protein (80-320AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMARCC1

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Alternative Name: SMARCC1 (SMARCC1 Products)

Synonyms: smarcc1 antibody, MGC53976 antibody, BAF155 antibody, CRACC1 antibody, Rsc8 antibody, SRG3 antibody, SWI3 antibody, AI115498 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 antibody, smarcc1.L antibody, smarcc1a antibody, SMARCC1 antibody, Smarcc1 antibody

Background:

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Aliases: AI115498 antibody, BAF 155 antibody, BAF155 antibody, BRG 1 associated factor 155 antibody, BRG1 associated factor 155 antibody, BRG1-associated factor 155 antibody, Chromatin remodeling complex BAF155 subunit antibody, CRACC 1 antibody, CRACC1 antibody, Mammalian chromatin remodeling complex BRG 1 associated factor 155 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 155 antibody, Rsc 8 antibody, Rsc8 antibody, SMARC C1 antibody, SMARCC 1 antibody, SMARCC1 antibody, SMRC1_HUMAN antibody, SRG 3 antibody, SRG3 antibody, SWI 3 antibody, SWI/SNF complex 155 kDa subunit antibody, SWI/SNF complex subunit SMARCC1 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin c1 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 antibody, SWI3 antibody

UniProt: Q92922

Pathways: Chromatin Binding