NLRP3 antibody (AA 1-153) (FITC)

Catalog No. ABIN7177712

This Rabbit Polyclonal antibody specifically detects NLRP3 in . It exhibits reactivity toward Mouse.

Quick Overview for NLRP3 antibody (AA 1-153) (FITC) (ABIN7177712)

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP3 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-NLRP3 Antibody (FITC)

Binding Specificity: AA 1-153

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 protein (1-153AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NLRP3

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Alternative Name: Nlrp3

Background:

Background: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, beta-amyloid fibers, environmental or industrial particles and nanoparticles, etc. However, it is unclear what constitutes the direct NLRP3 activator. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5\'-GRRGGNRGAG-3\'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (PubMed:26098997).

Aliases: Nlrp3 antibody, Cias1 antibody, Mmig1 antibody, Nalp3 antibody, Pypaf1 antibody, NACHT antibody, LRR and PYD domains-containing protein 3 antibody, Cold autoinflammatory syndrome 1 protein homolog antibody, Cryopyrin antibody, Mast cell maturation-associated-inducible protein 1 antibody, PYRIN-containing APAF1-like protein 1 antibody

UniProt: Q8R4B8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome