Angiotensin I Converting Enzyme 1 antibody (AA 1046-1263)

Catalog No. ABIN7178777

This Rabbit Polyclonal antibody specifically detects Angiotensin I Converting Enzyme 1 in IHC and ELISA. It exhibits reactivity toward Rat.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (AA 1046-1263) (ABIN7178777)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Binding Specificity: AA 1046-1263

Purpose: Ace Antibody

Cross-Reactivity: Rat

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Rat Angiotensin-converting enzyme protein (1046-1263AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: Ace

Background:

Background: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).

Aliases: Ace antibody, Dcp1 antibody, Angiotensin-converting enzyme antibody, ACE antibody, EC 3.2.1.- antibody, EC 3.4.15.1 antibody, Dipeptidyl carboxypeptidase I antibody, Kininase II antibody, CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme antibody, soluble form] antibody

UniProt: P47820

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration