VP35 (AA 1-329) antibody (FITC)

Catalog No. ABIN7179137

Product Details

Target: VP35

Binding Specificity: AA 1-329

Reactivity: Reston Ebola virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: FITC

Application: Please inquire

Cross-Reactivity: Reston Ebola virus

Purification: >95%, Protein G purified

Immunogen: Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: VP35

Background:

Background: Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.

Aliases: VP35 antibody, Polymerase cofactor VP35 antibody

UniProt: Q91DE0