PTGS2 antibody

Catalog No. ABIN7180881

Product Details anti-PTGS2 Antibody

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human Cox2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTGS2

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Alternative Name: PTGS2 (PTGS2 Products)

Synonyms: COX-2 antibody, COX2 antibody, GRIPGHS antibody, PGG/HS antibody, PGHS-2 antibody, PHS-2 antibody, hCox-2 antibody, Cox-2 antibody, Pghs2 antibody, TIS10 antibody, Cox2 antibody, cox-2 antibody, CEF147 antibody, PGHS2 antibody, PHSII antibody, cox2 antibody, gripghs antibody, pgg/hs antibody, pghs-2 antibody, phs-2 antibody, PTGS2 antibody, hcox-2 antibody, fj02a10 antibody, ptgs2 antibody, unp1239 antibody, wu:fj02a10 antibody, zCOX-2 antibody, si:dkey-97o5.6 antibody, prostaglandin-endoperoxide synthase 2 antibody, prostaglandin G/H synthase 2 antibody, prostaglandin-endoperoxide synthase 2S homeolog antibody, prostaglandin-endoperoxide synthase 2a antibody, prostaglandin-endoperoxide synthase 2b antibody, PTGS2 antibody, Ptgs2 antibody, LOC100136456 antibody, ptgs2.S antibody, ptgs2 antibody, ptgs2a antibody, ptgs2b antibody

Background:

Background: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Nathalie Bonnefoy, Mol. Cell. Biol., Apr 2001, 21: 2359 - 2372.
Keith P. Choe, J. Exp. Biol., May 2006, 209: 1696 - 1708
D. Shelley Lupold, PNAS, Sep 1999, 96: 11670.
Axel J. Baumgarten, AACR Meeting Abstracts, Mar 2004, 2004: 1078.

Aliases: COX 2 antibody, COX-2 antibody, COX2 antibody, Cyclooxygenase 2 antibody, Cyclooxygenase 2b antibody, Cyclooxygenase antibody, Cyclooxygenase-2 antibody, Cyclooxygenase2 antibody, EC 1.14.99.1 antibody, fj02a10 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody, GRIPGHS antibody, hCox 2 antibody, Macrophage activation-associated marker protein P71/73 antibody, OTTHUMP00000033524 antibody, PES-2 antibody, PGG/HS antibody, PGH synthase 2 antibody, PGH2_HUMAN antibody, PGHS 2 antibody, PGHS-2 antibody, PGHS2 antibody, PHS 2 antibody, PHS II antibody, PHS2 antibody, Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody, Prostaglandin endoperoxide synthase 2 antibody, Prostaglandin G/H synthase 2 antibody, Prostaglandin G/H synthase 2 precursor antibody, Prostaglandin G/H synthase and cyclooxygenase antibody, Prostaglandin G/H synthase antibody, Prostaglandin H2 synthase 2 antibody, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody, Prostaglandin-endoperoxide synthase 2 antibody, PTGS2 antibody, ptgs2a antibody, TIS10 antibody, TIS10 protein antibody, unp1239 antibody, wu:fj02a10 antibody

UniProt: P35354

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation