CYP2C8 antibody

Catalog No. ABIN7183419

Product Details anti-CYP2C8 Antibody

Target: CYP2C8 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2C8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human Cytochrome P450 2C8.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CYP2C8

Target: CYP2C8 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

Alternative Name: CYP2C8 (CYP2C8 Products)

Synonyms: CPC8 antibody, CYPIIC8 antibody, MP-12/MP-20 antibody, CYP2C74 antibody, cpc8 antibody, cyp2c8 antibody, cypiic8 antibody, mp-12/mp-20 antibody, cytochrome P450 family 2 subfamily C member 8 antibody, Cytochrome P450 2C8 antibody, cytochrome P450, family 2, subfamily C, polypeptide 8 antibody, cytochrome P450 family 2 subfamily C member 8 S homeolog antibody, CYP2C8 antibody, CTN_0597 antibody, cyp2c8.1.S antibody, cyp2c8.1 antibody

Background:

Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Romkes M., Biochemistry 30:3247-3255(1991).
Ged C., Biochim. Biophys. Acta 1088:433-435(1991).
Zeldin D.C., Arch. Biochem. Biophys. 322:76-86(1995).

Aliases: CP2C8_HUMAN antibody, CPC8 antibody, CYP2C8 antibody, CYPIIC8 antibody, Cytochrome P450 2C8 antibody, Cytochrome P450 family 2 subfamily C polypeptide 8 antibody, Cytochrome P450 form 1 antibody, Cytochrome P450 IIC2 antibody, Cytochrome P450 MP-12 antibody, Cytochrome P450 MP-20 antibody, Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8 antibody, Flavoprotein linked monooxygenase antibody, Microsomal monooxygenase antibody, MP 12/MP 20 antibody, P450 form 1 antibody, P450 IIC2 antibody, P450 MP 12/MP 20 antibody, S mephenytoin 4 hydroxylase antibody, S-mephenytoin 4-hydroxylase antibody, Xenobiotic monooxygenase antibody

UniProt: P10632