DLC1 antibody

Catalog No. ABIN7184062

Product Details anti-DLC1 Antibody

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human RHG07.

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Alternative Name: DLC1 (DLC1 Products)

Synonyms: ARHGAP7 antibody, HP antibody, STARD12 antibody, p122-RhoGAP antibody, rhogap7 antibody, DLC-1 antibody, StARD12 antibody, Dlc-1 antibody, A730069N07Rik antibody, Arhgap7 antibody, dlc-1 antibody, RhoGAP antibody, Dlc1 antibody, DLC1 Rho GTPase activating protein antibody, DLC1 Rho GTPase activating protein S homeolog antibody, rho GTPase-activating protein 7 antibody, deleted in liver cancer 1 antibody, DLC1 antibody, dlc1.S antibody, dlc1 antibody, LOC100456847 antibody, Dlc1 antibody, LOC100729904 antibody

Background:

Background: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Yuan B.Z., Cancer Res. 58:2196-2199(1998).
Nagase T., DNA Res. 7:347-355(2000).
Wilson P.J., Hum. Mutat. 15:156-165(2000).

Aliases: ARHGAP 7 antibody, ARHGAP7 antibody, Deleted in liver cancer 1 antibody, Deleted in liver cancer 1 protein antibody, DLC 1 antibody, Dlc-1 antibody, DLC1 antibody, DLC1 Rho GTPase activating protein antibody, FLJ21120 antibody, HP antibody, HP protein antibody, KIAA1723 antibody, p122 RhoGAP antibody, RHG07_HUMAN antibody, Rho GTPase activating protein 7 antibody, Rho GTPase-activating protein 7 antibody, Rho type GTPase activating protein 7 antibody, Rho-type GTPase-activating protein 7 antibody, StAR related lipid transfer (START) domain containing 12 antibody, StAR related lipid transfer protein 12 antibody, StAR-related lipid transfer protein 12 antibody, STARD 12 antibody, StARD12 antibody, START domain containing protein 12 antibody, START domain-containing protein 12 antibody

UniProt: Q96QB1

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity