BAP1 antibody (AA 150-230)

Catalog No. ABIN7227462

The Rabbit Polyclonal anti-BAP1 antibody is suitable to detect BAP1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for BAP1 antibody (AA 150-230) (ABIN7227462)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BAP1 Antibody

Binding Specificity: AA 150-230

Purpose: Rabbit Anti-BAP1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of BAP1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human BAP1 protein at AA range: 150-230

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: BAP1

Background: Ubiquitin carboxyl-terminal hydrolase BAP1, BRCA1-associated protein 1, Cerebral protein 6BAP1 (BRCA1 Associated Protein 1) is a Protein Coding gene. Diseases associated with BAP1 include Tumor Predisposition Syndrome and Bap1 Tumor Predisposition Syndrome. Among its related pathways are DNA Double Strand Break Response and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. BAP1 belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics.

Molecular Weight: 80kD

Gene ID: 8314

UniProt: Q92560