GCKR antibody (AA 180-260)

Catalog No. ABIN7221014

The Rabbit Polyclonal anti-GCKR antibody has been validated for WB and ELISA. It is suitable to detect GCKR in samples from Human, Rat and Mouse.

Quick Overview for GCKR antibody (AA 180-260) (ABIN7221014)

Target: GCKR (Glucokinase (Hexokinase 4) Regulator (GCKR))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCKR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GCKR Antibody

Binding Specificity: AA 180-260

Purpose: GCKR Polyclonal Antibody

Specificity: GCKR Polyclonal Antibody detects endogenous levels of GCKR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human GCKR at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for GCKR

Target: GCKR (Glucokinase (Hexokinase 4) Regulator (GCKR))

Alternative Name: GCKR

Background: Rabbit Anti-GCKR Polyclonal Antibody,GCKR, Glucokinase regulatory protein, Glucokinase regulator,GCKR encodes glucokinase regulator belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. GCKR is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).,Glucokinase regulatory protein

Molecular Weight: observerd band 68kDa

Gene ID: 2646

UniProt: Q14397

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus