Recombinant Neurofibromin 1 antibody (C-Term)

Catalog No. ABIN7795775

This Rabbit Monoclonal antibody specifically detects Neurofibromin 1 in WB, IP and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for Recombinant Neurofibromin 1 antibody (C-Term) (ABIN7795775)

Target: Neurofibromin 1 (NF1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Neurofibromin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: BLR345M

Product Details anti-Neurofibromin 1 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-Neurofibromin 1 Recombinant Monoclonal Antibody [BLR345M]

Purification: Purified

Immunogen: between 2789 and 2839 (C-term)

Isotype: IgG

Application Details

Application Notes: IP,20 μL/mg lysate,WB,11000,Flow-Cyt,Fixed in 4 % formaldehyde and permeabilized with 90 % methanol. 1 μL per 1 x 10^6 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: Neurofibromin 1

Background: Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.

Gene ID: 4763

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity