RPS6KB2 antibody (pSer423)

Catalog No. ABIN7224116

The Rabbit Polyclonal anti-RPS6KB2 antibody (ABIN7224116) specifically detects RPS6KB2 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for RPS6KB2 antibody (pSer423) (ABIN7224116)

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RPS6KB2 Antibody

Binding Specificity: pSer423

Purpose: Rabbit Anti-p70 S6 kinase β (phospho Ser423) Polyclonal Antibody

Specificity: Phospho-p70 S6 kinase β (S423) Polyclonal Antibody detects endogenous levels of p70 S6 kinase β protein only when phosphorylated at S423.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human p70 S6 kinase beta Phospho-Ser423

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RPS6KB2

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Alternative Name: p70 S6 kinase beta

Background: RPS6KB2, STK14B, Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70RPS6KB2 (ribosomal protein S6 kinase B2) encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Molecular Weight: 53kD

Gene ID: 6199

UniProt: Q9UBS0

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway