Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1) antibody
CASTOR1
Reactivity: Human
IF, IHC, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1)
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
- Purpose
- CASTOR1 Rabbit pAb
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human CASTOR1.
- Isotype
- IgG
-
- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1)
- Alternative Name
- CASTOR1
- Background
- Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.,GATSL3,CASTOR1
- Molecular Weight
- 36kDa
- Gene ID
- 652968
- UniProt
- Q8WTX7
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