NR1H2 antibody (AA 150-250)

Catalog No. ABIN7269011

Product Details anti-NR1H2 Antibody

Target: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Binding Specificity: AA 150-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1H2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: NR1H2 Rabbit pAb

Sequence: KEAGMREQCV LSEEQIRKKK IRKQQQQESQ SQSQSPVGPQ GSSSSASGPG ASPGGSEAGS QGSGEGEGVQ LTAAQELMIQ QLVAAQLQCN KRSFSDQPKV T

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human NR1H2 (NP_009052.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NR1H2

Target: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Alternative Name: NR1H2 (NR1H2 Products)

Synonyms: NR1H2 antibody, lxr-b antibody, lxrb antibody, ner antibody, ner-i antibody, rip15 antibody, unr antibody, DKFZp468A0622 antibody, AI194859 antibody, LXR antibody, LXRB antibody, LXRbeta antibody, NER1 antibody, OR-1 antibody, RIP15 antibody, UR antibody, Unr antibody, Unr2 antibody, LXR-b antibody, NER antibody, NER-I antibody, UNR antibody, nuclear receptor subfamily 1 group H member 2 antibody, nuclear receptor subfamily 1, group H, member 2 antibody, nuclear receptor subfamily 1 group H member 2 L homeolog antibody, NR1H2 antibody, nr1h2 antibody, Nr1h2 antibody, nr1h2.L antibody

Background: The liver X receptors, LXRA (NR1H3, MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs, see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010],NR1H2,LXR-b,LXRB,NER,NER-I,RIP15,UNR,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Cancer,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,NR1H2

Molecular Weight: 39kDa/50kDa

Gene ID: 7376

UniProt: P55055

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding