PEN2 antibody

Catalog No. ABIN7269513

Product Details anti-PEN2 Antibody

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: PEN2/PSENEN Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human PEN2/PSENEN

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PSENEN (PSENEN Products)

Synonyms: MSTP064 antibody, PEN-2 antibody, PEN2 antibody, Psenen antibody, ACYPI006208 antibody, 1700023M09Rik antibody, Pen-2 antibody, RGD1312037 antibody, CG33198 antibody, Dmel\\CG33198 antibody, anon-AE003800.1 antibody, dPen-2 antibody, psenen antibody, pen-2 antibody, pen2 antibody, zgc:109727 antibody, presenilin enhancer gamma-secretase subunit antibody, presenilin enhancer 2 antibody, presenilin enhancer gamma secretase subunit antibody, Gamma-secretase subunit pen-2 antibody, presenilin enhancer antibody, presenilin enhancer gamma secretase subunit S homeolog antibody, PSENEN antibody, PEN2 antibody, Psenen antibody, pen-2 antibody, psenen.S antibody, psenen antibody

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],MDS033, MSTP064, PEN-2, PEN2,Cell Biology & Developmental Biology,ErbB-HER Signaling Pathway,ESC Pluripotency and Differentiation,Neurodegenerative Diseases,Neurodegenerative Diseases Markers,Neurodegenerative Diseases_Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Neuroscience,Notch Signaling Pathway,Signal Transduction,PSENEN

Molecular Weight: 13kDa

Gene ID: 55851

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway