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SLFN11 antibody

SLFN11 Reactivity: Human WB Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7270159
  • Target See all SLFN11 products
    SLFN11 (Schlafen Family Member 11 (SLFN11))
    Reactivity
    • 6
    • 1
    Human
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Monoclonal
    Conjugate
    • 2
    • 2
    • 1
    • 1
    This SLFN11 antibody is un-conjugated
    Application
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    SLFN11 Rabbit mAb
    Cross-Reactivity
    Human
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human SLFN11.
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SLFN11 (Schlafen Family Member 11 (SLFN11))
    Alternative Name
    SLFN11 (SLFN11 Products)
    Synonyms
    SLFN8/9 antibody, schlafen family member 11 antibody, SLFN11 antibody, LOC100071612 antibody
    Background
    Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1 by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.,SLFN8/9,SLFN11
    Molecular Weight
    102kDa
    Gene ID
    91607
    UniProt
    Q7Z7L1
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