SEPN1 antibody (AA 341-590)
-
- Target See all SEPN1 Antibodies
- SEPN1 (Selenoprotein N, 1 (SEPN1))
-
Binding Specificity
- AA 341-590
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SEPN1 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Purpose
- SEPN1 Rabbit pAb
- Sequence
- VDMEWLYGAS ESSNMEVDIG YIPQMELEAT GPSVPSVILD EDGSMIDSHL PSGEPLQFVF EEIKWQQELS WEEAARRLEV AMYPFKKVSY LPFTEAFDRA KAENKLVHSI LLWGALDDQS CUGSGRTLRE TVLESSPILT LLNESFISTW SLVKELEELQ NNQENSSHQK LAGLHLEKYS FPVEMMICLP NGTVVHHINA NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 341-590 of human SEPN1 (NP_065184.2).
- Isotype
- IgG
- Top Product
- Discover our top product SEPN1 Primary Antibody
-
-
- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- SEPN1 (Selenoprotein N, 1 (SEPN1))
- Alternative Name
- SEPN1 (SEPN1 Products)
- Synonyms
- CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, SELN antibody, 1110019I12Rik antibody, AI414492 antibody, SePN antibody, cb686 antibody, wu:fb06g01 antibody, wu:fb73d02 antibody, wu:fv41b08 antibody, zgc:101091 antibody, selenoprotein N antibody, SELENON antibody, Selenon antibody, selenon antibody
- Background
- This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.,SELENON,CFTD,MDRS1,RSMD1,RSS,SELN,SEPN1,SEPN1
- Molecular Weight
- 62kDa/65kDa
- Gene ID
- 57190
- UniProt
- Q9NZV5
- Pathways
- Skeletal Muscle Fiber Development
-