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SEPN1 antibody (AA 341-590)

SEPN1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7270196
  • Target See all SEPN1 Antibodies
    SEPN1 (Selenoprotein N, 1 (SEPN1))
    Binding Specificity
    • 13
    • 8
    • 7
    AA 341-590
    Reactivity
    • 29
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 29
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SEPN1 antibody is un-conjugated
    Application
    • 22
    • 17
    • 13
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    SEPN1 Rabbit pAb
    Sequence
    VDMEWLYGAS ESSNMEVDIG YIPQMELEAT GPSVPSVILD EDGSMIDSHL PSGEPLQFVF EEIKWQQELS WEEAARRLEV AMYPFKKVSY LPFTEAFDRA KAENKLVHSI LLWGALDDQS CUGSGRTLRE TVLESSPILT LLNESFISTW SLVKELEELQ NNQENSSHQK LAGLHLEKYS FPVEMMICLP NGTVVHHINA NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 341-590 of human SEPN1 (NP_065184.2).
    Isotype
    IgG
    Top Product
    Discover our top product SEPN1 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SEPN1 (Selenoprotein N, 1 (SEPN1))
    Alternative Name
    SEPN1 (SEPN1 Products)
    Synonyms
    CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, SELN antibody, 1110019I12Rik antibody, AI414492 antibody, SePN antibody, cb686 antibody, wu:fb06g01 antibody, wu:fb73d02 antibody, wu:fv41b08 antibody, zgc:101091 antibody, selenoprotein N antibody, SELENON antibody, Selenon antibody, selenon antibody
    Background
    This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.,SELENON,CFTD,MDRS1,RSMD1,RSS,SELN,SEPN1,SEPN1
    Molecular Weight
    62kDa/65kDa
    Gene ID
    57190
    UniProt
    Q9NZV5
    Pathways
    Skeletal Muscle Fiber Development
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