ERBB4 antibody

Catalog No. ABIN7271256

The Rabbit Monoclonal anti-ERBB4 antibody (ABIN7271256) specifically detects ERBB4 in WB. The antibody is reactive with Human samples.

Quick Overview for ERBB4 antibody (ABIN7271256)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERBB4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERBB4 Antibody

Purpose: ErbB4/HER4 Rabbit mAb

Cross-Reactivity: Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human ErbB4/HER4

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: ERBB4

Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4,Cancer,Cell Biology & Developmental Biology,ErbB-HER Signaling Pathway,Growth factors,Growth factors_EGF,Immunology & Inflammation,Kinase,Kinase_Tyrosine kinases,Protein phosphorylation,Signal Transduction,Tumor biomarkers,ERBB4

Molecular Weight: 160kDa

Gene ID: 2066

UniProt: Q15303

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway