tau antibody (AA 297-391) (FITC)
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- Target See all tau Antibodies
- tau (tau Protein)
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Binding Specificity
- AA 297-391
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This tau antibody is conjugated to FITC
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Application
- Western Blotting (WB)
- Purpose
- Rabbit Anti-Human Truncated Tau Fragment (AA297-391) (dGAE) Polyclonal,
- Specificity
- Widely expressed, with high levels in brain.,Detects ~10.2 kDa.
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Protein A
- Immunogen
- Recombinant Human Tau AA297-391 (dGAE) Fibril (SPR-461)
- Top Product
- Discover our top product tau Primary Antibody
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- Application Notes
- WB (1:1000), optimal dilutions for assays should be determined by the user.
- Comment
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A 1:1000 dilution was sufficient for detection of tau in 15 μg of mouse, rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Conjugated antibodies should be stored at 4°C
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- Target
- tau (tau Protein)
- Abstract
- tau Products
- Synonyms
- DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, tau antibody, PHF-tau antibody, microtubule associated protein tau antibody, MAPT antibody
- Background
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3)., cellular localisation: Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex
- Gene ID
- 4137
- NCBI Accession
- NP_005901
- UniProt
- P10636
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