Caspase 8 antibody

Catalog No. ABIN7384425

The Rabbit Monoclonal anti-Caspase 8 antibody has been validated for WB. It is suitable to detect Caspase 8 in samples from Hamster.

Quick Overview for Caspase 8 antibody (ABIN7384425)

Target: Caspase 8 (CASP8)

Reactivity: Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caspase 8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R02-0D7

Product Details anti-Caspase 8 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Caspase 8

Target: Caspase 8 (CASP8)

Alternative Name: Caspase 8

Background: ALPS2B,Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein,Apoptotic cysteine protease,Apoptotic protease Mch-5,Apoptotic protease Mch5,CAP4,CASP-8,CASP8,CASP8,Caspase 8,Caspase 8 apoptosis related cysteine peptidase,Caspase-8 subunit p10,CED 3,FADD Like ICE,FADD-homologous ICE/CED-3-like protease,FADD-like ICE,FLICE,FLJ17672,ICE-like apoptotic protease 5,MACH alpha 1/2/3 protein,MACH,MACH beta 1/2/3/4 protein,MCH5,MGC78473,MORT1 associated ced 3 homolog,MORT1-associated CED-3 homolog,OTTHUMP00000163717,OTTHUMP00000163720,OTTHUMP00000163724,OTTHUMP00000163725,OTTHUMP00000165062,OTTHUMP00000165063,OTTHUMP00000165064,OTTHUMP00000206552,OTTHUMP00000206582,Caspase 8,also named as MCH5,MACH,FLICE,and CAP4,belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3. It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. Caspase 8 Monoclonal Antibody can recognize pro- and cleaved-caspase 8.

Molecular Weight:

Observed_MW: 55kDa

Calculated_MW: 55kDa

Gene ID: 841

UniProt: Q14790

Pathways: Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades