eIF4EBP1 antibody (C-Term)

Catalog No. ABIN7448395

This Rabbit Polyclonal antibody specifically detects eIF4EBP1 in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for eIF4EBP1 antibody (C-Term) (ABIN7448395)

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This eIF4EBP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-eIF4EBP1 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-4EBP1 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,Rabbit,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,Chinese hamster,Thirteen-lined ground squirrel,Crab-eating macaque

Purification: Affinity Purified

Immunogen: Between AA 75 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for eIF4EBP1

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Alternative Name: 4EBP1

Background: Background: Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed.

Gene ID: 1978

NCBI Accession: NP_004086

UniProt: Q13541

Pathways: MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling