CDK8 antibody (AA 420-470)

Catalog No. ABIN7448472

This anti-CDK8 antibody is a Rabbit Polyclonal antibody detecting CDK8 in IHC. Suitable for Human.

Quick Overview for CDK8 antibody (AA 420-470) (ABIN7448472)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK8 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CDK8 Antibody

Binding Specificity: AA 420-470

Purpose: Rabbit anti-CDK8 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Chicken,Turkey,Bovine,Dog,Horse,Rabbit,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,Tasmanian devil,White-tufted-ear marmoset,African elephant,Green anole,Small-eared galago,Naked mole rat,Gray short-tailed opossum,Chinese hamster,Zebra finch,Duckbill platypus,Northern white-cheeked gibbon,Thirteen-lined ground squirrel,Little brown bat

Purification: Affinity Purified

Immunogen: Between AA 420 and 470

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Alternative Name: CDK8

Background: Background: Cyclin-dependent kinase 8 (CDK8) associates with cyclin C and is a component of the RNA polymerase II holoenzyme complex which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery [taken from NCBI Entrez Gene (GeneID: 1024)].

Gene ID: 1024

NCBI Accession: NP_001251

UniProt: P49336

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha