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CDK8 antibody (N-Term)

CDK8 Reactivity: Human WB Host: Rabbit Polyclonal RB3200 unconjugated
Catalog No. ABIN391759
  • Target See all CDK8 Antibodies
    CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
    Binding Specificity
    • 13
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 81
    • 39
    • 28
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 77
    • 3
    • 1
    Rabbit
    Clonality
    • 69
    • 12
    Polyclonal
    Conjugate
    • 40
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDK8 antibody is un-conjugated
    Application
    • 67
    • 34
    • 13
    • 11
    • 10
    • 9
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDK8.
    Clone
    RB3200
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CDK8 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Han, Zheng, Ge, Wang, Xiang, Wang: "Downregulation of cyclin-dependent kinase 8 by microRNA-148a suppresses proliferation and invasiveness of papillary thyroid carcinomas." in: American journal of cancer research, Vol. 7, Issue 10, pp. 2081-2090, (2018) (PubMed).

  • Target
    CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
    Alternative Name
    CDK8 (CDK8 Products)
    Synonyms
    K35 antibody, wu:fk95h11 antibody, cyclin dependent kinase 8 antibody, cyclin-dependent kinase 8 antibody, cyclin-dependent kinase 8 S homeolog antibody, Cyclin-dependent kinase 8 antibody, cyclin dependent kinase 19 antibody, CDK8 antibody, Cdk8 antibody, cdk8 antibody, cdk8.S antibody, cdk-8 antibody, CDK19 antibody
    Background
    CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
    Molecular Weight
    53284
    Gene ID
    1024
    NCBI Accession
    NP_001251
    UniProt
    P49336
    Pathways
    Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
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