RNF40 antibody (AA 540-590)

Catalog No. ABIN7448780

Product Details anti-RNF40 Antibody

Target: RNF40 (Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40))

Binding Specificity: AA 540-590

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF40 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purpose: Rabbit anti-RNF40 IHC Antibody, Affinity Purified

Predicted Reactivity: Monkey,Gorilla,Chimpanzee,Crab-eating macaque,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 540 and 590

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RNF40

Target: RNF40 (Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40))

Alternative Name: RNF40 (RNF40 Products)

Synonyms: AI848422 antibody, mKIAA0661 antibody, BRE1B antibody, RBP95 antibody, STARING antibody, ring finger protein 40 antibody, RNF40 antibody, Rnf40 antibody

Background: Background: The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 40 (RNF40) is a member of the RING type E3 ubiquitin ligases. RNF40 forms a complex with RNF20 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RN40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.

Gene ID: 9810

NCBI Accession: NP_055586

UniProt: O75150