CDK8 antibody (AA 370-420)

Catalog No. ABIN7451212

This Rabbit Polyclonal antibody specifically detects CDK8 in IP. It exhibits reactivity toward Human.

Quick Overview for CDK8 antibody (AA 370-420) (ABIN7451212)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK8 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-CDK8 Antibody

Binding Specificity: AA 370-420

Purpose: Rabbit anti-CDK8 Antibody, Affinity Purified

Predicted Reactivity: Mouse,X. laevis,X. tropicalis

Purification: Affinity Purified

Immunogen: between AA 370 and 420

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-CDK8 antibody ABIN7453676.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Alternative Name: CDK8

Background: Background: Cyclin-dependent kinase 8 (CDK8) associates with cyclin C and is a component of the RNA polymerase II holoenzyme complex which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery [taken from NCBI Entrez Gene (GeneID: 1024)].

Gene ID: 1024

NCBI Accession: NP_001251

UniProt: P49336

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha