RC3H1 antibody (AA 500-550)

Catalog No. ABIN7452216

The Rabbit Polyclonal anti-RC3H1 antibody (ABIN7452216) specifically detects RC3H1 in WB and IP. The antibody is reactive with Human and Mouse samples.

Quick Overview for RC3H1 antibody (AA 500-550) (ABIN7452216)

Target: RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RC3H1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RC3H1 Antibody

Binding Specificity: AA 500-550

Purpose: Rabbit anti-Roquin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 500 and 550

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:500 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RC3H1

Target: RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))

Alternative Name: Roquin

Background: Background: The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. Roquin is a member of the RING type E3 ubiquitin ligases. Roquin possesses a CCCH zinc-finger found in RNA-binding proteins and is implicated to play a role in the development of autoimmune disease.

Gene ID: 149041

NCBI Accession: NP_742068

UniProt: Q5TC82

Pathways: Ribonucleoprotein Complex Subunit Organization, Activated T Cell Proliferation