RC3H1 antibody (C-Term)

Catalog No. ABIN7464126

Product Details anti-RC3H1 Antibody

Target: RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RC3H1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human RC3H1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T , A431 , HeLa , HepG2 , 3xFlag-human RC3H1 transfected 293T

Validation: Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for RC3H1

Target: RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))

Alternative Name: ring finger and CCCH-type domains 1 (RC3H1 Products)

Synonyms: RNF198 antibody, ROQUIN antibody, RC3H1 antibody, si:dkey-192m14.4 antibody, 5730557L09Rik antibody, Gm551 antibody, N28103 antibody, mKIAA2025 antibody, RGD1563512 antibody, rc3h1 antibody, ring finger and CCCH-type domains 1 antibody, ring finger and CCCH-type domains 1a antibody, ring finger and CCCH-type zinc finger domains 1 antibody, RING CCCH (C3H) domains 1 antibody, ring finger and CCCH-type domains 1 L homeolog antibody, RC3H1 antibody, rc3h1a antibody, Rc3h1 antibody, rc3h1.L antibody

Background: Ring finger and CCCH-type domains 1 , RNF198 , ROQUIN,RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.[supplied by OMIM]

Molecular Weight: 126 kDa

Gene ID: 149041

UniProt: Q5TC82

Pathways: Ribonucleoprotein Complex Subunit Organization, Activated T Cell Proliferation