ALIX antibody (AA 818-868)

Catalog No. ABIN7453859

The Rabbit Polyclonal anti-ALIX antibody has been validated for WB, IP and IHC (fp). It is suitable to detect ALIX in samples from Human.

Quick Overview for ALIX antibody (AA 818-868) (ABIN7453859)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-ALIX Antibody

Binding Specificity: AA 818-868

Purpose: Rabbit anti-ALIX Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: between AA 818 and 868

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: ALIX

Background: Background: ALIX (ALG-2 interacting protein X) is thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of ALIX can block apoptosis. ALIX has been shown to bind to the PDCD6 (programmed cell death 6 interacting protein), a protein required for apoptosis, in a calcium-dependent manner. ALIX also binds to endophilins, proteins that regulate membrane shape during endocytosis [taken from NCBI Entrez Gene (Gene ID: 10015].

Gene ID: 10015

NCBI Accession: NP_037506

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation