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Bcl-2 antibody (N-Term)

This Mouse Monoclonal antibody specifically detects Bcl-2 in WB and IHC (p). It exhibits reactivity toward Human.
Catalog No. ABIN7466193
$740.00
Plus shipping costs $50.00
100 μL
Shipping to: United States
Delivery in 3 to 5 Business Days

Quick Overview for Bcl-2 antibody (N-Term) (ABIN7466193)

Target

See all Bcl-2 (BCL2) Antibodies
Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity

  • 462
  • 184
  • 167
  • 36
  • 25
  • 24
  • 18
  • 9
  • 6
  • 5
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 364
  • 129
  • 4
  • 2
  • 2
  • 1
  • 1
Mouse

Clonality

  • 316
  • 186
Monoclonal

Conjugate

  • 213
  • 34
  • 28
  • 20
  • 19
  • 12
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
This Bcl-2 antibody is un-conjugated

Application

  • 390
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  • 162
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  • 116
  • 95
  • 81
  • 73
  • 56
  • 54
  • 23
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

GT11210
  • Binding Specificity

    • 55
    • 38
    • 27
    • 25
    • 22
    • 22
    • 16
    • 16
    • 16
    • 12
    • 11
    • 10
    • 7
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    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Cross-Reactivity

    Human

    Purification

    Affinity purified by Protein G.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bcl-2. The exact sequence is proprietary.

    Isotype

    IgG2b
  • Application Notes

    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Positive Control: human BCL2-transfected 293T cells

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS, No Preservative

    Preservative

    Without preservative

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

    Alternative Name

    BCL2 apoptosis regulator

    Background

    BCL2 apoptosis regulator , Bcl-2 , PPP1R50,This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq]

    Molecular Weight

    26 kDa

    Gene ID

    596

    UniProt

    P10415

    Pathways

    MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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