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TDG antibody

This Mouse Monoclonal antibody specifically detects TDG in WB and IHC (p). It exhibits reactivity toward Human.
Catalog No. ABIN7467207

Quick Overview for TDG antibody (ABIN7467207)

Target

See all TDG Antibodies
TDG (Thymine-DNA Glycosylase (TDG))

Reactivity

  • 50
  • 19
  • 11
  • 2
  • 2
Human

Host

  • 39
  • 11
Mouse

Clonality

  • 42
  • 9
Monoclonal

Conjugate

  • 44
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TDG antibody is un-conjugated

Application

  • 40
  • 14
  • 11
  • 11
  • 6
  • 6
  • 5
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

GT311
  • Cross-Reactivity

    Human, Mouse

    Purification

    Affinity purified by Protein A.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary.

    Isotype

    IgG2a
  • Application Notes

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Validation: Overexpression

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    1XPBS pH 7, 20 % Glycerol, No Preservative

    Preservative

    Without preservative

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    TDG (Thymine-DNA Glycosylase (TDG))

    Alternative Name

    thymine DNA glycosylase

    Background

    Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]

    Molecular Weight

    46 kDa

    Gene ID

    6996

    UniProt

    Q13569

    Pathways

    DNA Damage Repair, Chromatin Binding
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