NEIL1 antibody

Catalog No. ABIN7468300

Product Details anti-NEIL1 Antibody

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEIL1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human NEIL1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T , 293T nuclear extract , NEIL1-transfected 293T Validation: Orthogonal, Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for NEIL1

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Alternative Name: nei like DNA glycosylase 1 (NEIL1 Products)

Synonyms: FPG1 antibody, NEI1 antibody, hFPG1 antibody, 2810450N13Rik antibody, Nei1 antibody, nei-like DNA glycosylase 1 antibody, nei like DNA glycosylase 1 antibody, nei endonuclease VIII-like 1 (E. coli) antibody, Neil1 antibody, NEIL1 antibody

Background:

Synonyms: nei like DNA glycosylase 1 , FPG1 , NEI1 , hFPG1

Background: NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM]

Molecular Weight: 44 kDa

Gene ID: 79661

UniProt: Q96FI4

Pathways: DNA Damage Repair