Prostaglandin D2 Receptor 2 (PTGDR2) antibody
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- Target See all Prostaglandin D2 Receptor 2 (PTGDR2) Antibodies
- Prostaglandin D2 Receptor 2 (PTGDR2)
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Reactivity
- Human
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Flow Cytometry (FACS)
- Purpose
- Anti-Hu CD294 Purified
- Specificity
- The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils.
- Purification
- Purified by protein-G affinity chromatography.
- Immunogen
- Human CD294 transfected rat cell line TART/B19-12.10
- Clone
- BM16
- Isotype
- IgG2a
- Top Product
- Discover our top product PTGDR2 Primary Antibody
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- Application Notes
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- Prostaglandin D2 Receptor 2 (PTGDR2)
- Alternative Name
- CD294 (PTGDR2 Products)
- Synonyms
- CD294 antibody, CRTH2 antibody, DL1R antibody, DP2 antibody, GPR44 antibody, Crth2 antibody, Grp45 antibody, Ptgdr2 antibody, Gpr44 antibody, prostaglandin D2 receptor 2 antibody, PTGDR2 antibody, Ptgdr2 antibody
- Background
- Prostaglandin D2 receptor 2,CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.,DP2, PTGDR2, DL1R, CRTH2, GPR44
- Gene ID
- 11251
- UniProt
- Q9Y5Y4
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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