TOMM34 antibody

Catalog No. ABIN7506232

Product Details anti-TOMM34 Antibody

Target: TOMM34 (Translocase of Outer Mitochondrial Membrane 34 (TOMM34))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOMM34 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Purpose: Anti-Hu Tomm34 Purified

Specificity: The mouse monoclonal antibody Tomm34-4.1 recognizes an epitope within TPR2 domain of human Tomm34 protein.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Recombinant human Tomm34

Clone: Tomm34-4-1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for TOMM34

Target: TOMM34 (Translocase of Outer Mitochondrial Membrane 34 (TOMM34))

Alternative Name: Tomm34 (TOMM34 Products)

Synonyms: HTOM34P antibody, TOM34 antibody, URCC3 antibody, 2610100K07Rik antibody, Tomm34a antibody, Tomm34b antibody, zC239J9.1 antibody, zgc:56645 antibody, wu:fb96b08 antibody, TOMM34 antibody, translocase of outer mitochondrial membrane 34 antibody, TOMM34 antibody, Tomm34 antibody, tomm34 antibody, LOC100305086 antibody

Background: Translocase of outer mitochondrial membrane 34,Tomm34 (translocase of the outer mitochondrial membrane 34) is an additional component of the cellular chaperone system involved in protein folding. As the name suggests, Tomm34 was initially identified as being involved in mitochondrial protein processing. Subsequent studies have shown that Tomm34 interacts with both Hsp70 and Hsp90 and modifies their protein folding activities. In cancer, high levels of Tomm34 have been reported in bladder, colorectal and breast cancers compared to their normal tissue counterparts. In these cancers, Tomm34 promotes colorectal cancer cell growth and is a biomarker of poor outcome in early invasive breast cancer and bladder cancer. As a tumour-associated protein, Tomm34 peptide vaccination is under investigation as a therapeutic option for colorectal cancer, with significant Tomm34 cytotoxic T-lymphocyte (CTL) response observed.,URCC3, HTOM34P

Gene ID: 10953

UniProt: Q15785