Insulin Receptor antibody

Catalog No. ABIN7538096

This Rabbit Polyclonal antibody specifically detects Insulin Receptor in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Insulin Receptor antibody (ABIN7538096)

Target: Insulin Receptor (INSR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Insulin Receptor Antibody

Purpose: Rabbit polyclonal antibodies to Insulin Receptor

Specificity: Insulin receptor

Cross-Reactivity (Details): May cross-react with other species

Purification: Immunogen affinity column

Immunogen: Peptide conjugated to KLH (GGKKNGRILTLPRSNPS)

Isotype: IgG, IgM

Application Details

Application Notes: Western blot: 0.1-1.0 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Glycine pH 7.2

Storage: 4 °C,-80 °C

Storage Comment: Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: insulin receptor

Background: INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

Molecular Weight: 42226 Da

Gene ID: 3643

NCBI Accession: NP_000199

UniProt: P06213

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity