Recombinant Estrogen Receptor alpha antibody

Catalog No. ABIN7543365

The Rabbit Chimeric anti-Estrogen Receptor alpha antibody is suitable to detect Estrogen Receptor alpha in samples from Human. It has been validated for ELISA.

Quick Overview for Recombinant Estrogen Receptor alpha antibody (ABIN7543365)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This Estrogen Receptor alpha antibody is un-conjugated

Application: ELISA

Clone: 4E11

Product Details anti-Estrogen Receptor alpha Antibody

Purpose: Anti-Estrogen receptor [4E11], Rabbit IgG, kappa

Specificity: The antibody is specific for estrogen receptor ER-α36. The estrogen receptor ER-α36 is an estrogen receptor subtype mainly expressed on the cell membrane, it mediates the non-genomic estrogen signal pathway, and can inhibit the traditional estrogen signal pathway. It plays a vital role in the occurrence and development of diseases. For example its expression level is closely related to some biological indicators of cancer.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with estrogen receptor ER-alpha36.

Isotype: IgG kappa

Application Details

Application Notes: The antibody specifically recognized ER-α36 protein expressed by SUM159 cells, as confirmed by ELISA analysis (CN107987164).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Alternative Name: Estrogen receptor

Background: ER, ERα36, ER-α36, hER-α36, ESR1, ER-alpha, NR3A1, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ER-alpha Estradiol receptor, Nuclear receptor subfamily 3 group A member 1

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly