Caspase 9 antibody (Caspase 9, Apoptosis-Related Cysteine Peptidase) (AA 20-69)

Details for Product anti-CASP9 Antibody No. ABIN724160, Supplier: Log in to see
Antigen
  • CASP9
  • AI115399
  • APAF-3
  • AW493809
  • CASP-9
  • Caspase-9
  • ICE-LAP6
  • Mch6
  • Apaf3
  • Casp-9-CTD
  • Casp9_v1
  • Ice-Lap6
  • APAF3
  • MCH6
  • PPP1R56
  • caspase 9
  • CASP9
  • Casp9
Epitope
AA 20-69
42
23
21
18
16
15
15
15
14
11
11
11
9
9
7
6
6
5
5
5
5
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
426
143
132
22
11
8
6
5
4
4
3
1
Host
Rabbit
419
47
Clonality
Polyclonal
Conjugate
This Caspase 9 antibody is un-conjugated
10
10
7
4
4
4
4
4
4
4
4
4
4
4
4
3
3
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
403
151
138
89
75
67
52
32
23
15
13
10
6
2
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human Caspase 9 subunit p35
Isotype IgG
Purification Purified by Protein A.
Alternative Name Caspase 9 (CASP9 Antibody Abstract)
Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Subcellular location: Cytoplasm

Synonyms: MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6, CASP9

Gene ID 842
UniProt P55211
Pathways MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
Application Notes WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 20-69) antibody (ABIN724160) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Caspase-...
Immunohistochemistry (IHC) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 20-69) antibody (ABIN724160) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Caspase-9 Polyclonal...
Western Blotting (WB) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 20-69) antibody (ABIN724160) Raji lysates probed with Rabbit Anti-Caspase 9 Polyclonal Antibody, Unconjugated at ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 20-69) antibody (ABIN724160) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Caspase-...
Flow Cytometry (FACS) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 20-69) antibody (ABIN724160) RSC96 probed with Caspase 9 Polyclonal Antibody, Unconjugated at 1:100 for 30 minute...
Product cited in: Wang, Xuan, Cui, Wang, Chen, Wei, Zhao: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, 2017 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)).

Wang, Wang, Huang, Yang, Zhao, Wei, Zhao: "Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways." in: Heart and vessels, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: myocardium of cardiomyopathy

Pan, Yang, Wang, Wang, Wang, Zhou, Yin, Zhang, Zhao: "C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 1102-16, 2014 (PubMed). (Sample species: Rat (Rattus)).

Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: "Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications." in: Basic research in cardiology, Vol. 109, Issue 5, pp. 427, 2014 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Dog (Canine)). Further details: Sample: Heart

Wang, Lu, Dai, Zhang, Wang, Wei: "Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway." in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], 2014 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Mouse (Murine)).

Wang, Han, Zhou, Wu, Wang, Jia, Lv, Cheng, Pan, Liu, Zhou, Sun: "Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway." in: Apoptosis : an international journal on programmed cell death, Vol. 18, Issue 1, pp. 28-42, 2013 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: pancreatic gland

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