MUTYH antibody (AA 1-559)

Catalog No. ABIN7599478

This Rabbit Polyclonal antibody specifically detects MUTYH in WB, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for MUTYH antibody (AA 1-559) (ABIN7599478)

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUTYH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-MUTYH Antibody

Binding Specificity: AA 1-559

Purpose: Anti-MUTYH Antibody

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Characteristics: Anti-MUTYH Antibody. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human IFFO1 recombinant protein (Position: M1-R559). Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MUTYH

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Alternative Name: MUTYH

Background:

Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: mutY DNA glycosylase

Molecular Weight: 60 kDa

Gene ID: 4595

UniProt: Q9UIF7

Pathways: DNA Damage Repair