Insulin Receptor antibody

Catalog No. ABIN7605279

This Rabbit Monoclonal antibody specifically detects Insulin Receptor in WB, ICC and IF. It exhibits reactivity toward Human and Rat.

Quick Overview for Insulin Receptor antibody (ABIN7605279)

Target: Insulin Receptor (INSR)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: GGA-9

Product Details anti-Insulin Receptor Antibody

Purpose: Anti-Insulin Receptor INSR Rabbit Monoclonal Antibody

Characteristics: Anti-Insulin Receptor INSR Rabbit Monoclonal Antibody (ABIN7605279). Tested in WB, ICC/IF applications. This antibody reacts with Human, Rat.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Insulin Receptor

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000
ICC/IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: INSR

Background:

Synonyms: Insulin receptor,IR,2.7.10.1,CD220,Insulin receptor subunit alpha,Insulin receptor subunit beta,INSR,

Tissue Specificity: Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. .

Molecular Weight: 73 kDa

UniProt: P06213

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity