LAMR1CT (AA 201-295) antibody

Catalog No. ABIN729598

Product Details

Target: LAMR1CT

Binding Specificity: AA 201-295

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LAMR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Liu, Sun, Wu, Shi, Wang, Wang, Zhang, Zhang, Zhang: "MGr1-Ag/37LRP promotes growth and proliferation of gastric cancer in vitro and in vivo." in: Cancer gene therapy, Vol. 21, Issue 9, pp. 355-63, (2014) (PubMed).

Zhang, Wang, Xu, Dong, Liu, Zhou, Pang, Ma, Zhang, Pei, Zhang, Liu: "MGr1-Ag promotes invasion and bone metastasis of small-cell lung cancer in vitro and in vivo." in: Oncology reports, Vol. 29, Issue 6, pp. 2283-90, (2013) (PubMed).

Target Details

Target: LAMR1CT

Background:

Synonyms: SA, LBP, LRP, p4, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p4, NEM/1CHD4, 4S ribosomal protein SA, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p4, Multidrug resistance-associated protein MGr1-Ag, RPSA

Background: Required for the assembly and/or stability of the 4S ribosomal subunit. Required for the processing of the 2S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 4S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.

Gene ID: 3921

UniProt: P08865