FLT3 antibody

Catalog No. ABIN7670058

This Mouse Monoclonal antibody specifically detects FLT3 in FACS. It exhibits reactivity toward Human.

Quick Overview for FLT3 antibody (ABIN7670058)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLT3 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: BV10(BV10A4)

Product Details anti-FLT3 Antibody

Purpose: Purified Anti-Human CD135 Antibody[BV10(BV10A4)]

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: CD135

Background: Fetal Liver Kinase,Fms-Like Tyrosine Kinase,Stem Cell Tyrosine Kinase,Receptor-Type Tyrosine-Protein Kinase FLT,FLT,FLK,STK,FLT3,CD135,FLK-2,FLK2,STK1,Fetal Liver Kinase-2,FL Cytokine Receptor,FLT-3,Fms-Like Tyrosine Kinase 3,Receptor-Type Tyrosine-Protein Kinase FLT3,Stem Cell Tyrosine Kinase 1,STK-1,Flt3/Flk2, STK-1,CD 135,CD135 antigen,Fetal liver kinase 2,Flk 2,Flt 3,FMS like tyrosine kinase 3,Fms related tyrosine kinase 3,Fms-Related Tyrosine Kinase 3,Growth factor receptor tyrosine kinase type III,Ly-72,OTTHUMP0000004234,Receptor type tyrosine protein kinase FLT3,Stk 1,Tyrosine protein kinase receptor FLT3,Tyrosine-protein kinase receptor FLT3,This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

UniProt: P36888

Pathways: RTK Signaling