Caspase 9 antibody

Catalog No. ABIN7670508

The Mouse Monoclonal anti-Caspase 9 antibody is suitable to detect Caspase 9 in samples from Human. It has been validated for WB.

Quick Overview for Caspase 9 antibody (ABIN7670508)

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Caspase 9 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3B6

Product Details anti-Caspase 9 Antibody

Purpose: Caspase-9 Monoclonal Antibody

Purification: Protein A/G Purification

Immunogen: Recombinant Human Caspase-9 protein expressed by E.coli

Isotype: IgG2a

Application Details

Application Notes: WB 1:250-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.05 % proclin 300, 1 % protective protein and 50 % glycerol, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Alternative Name: Caspase-9

Background: Apoptosis related cysteine peptidase,Apoptotic protease-activating factor 3,Caspase 9 apoptosis related cysteine peptidase,Caspase 9 Dominant Negative,Caspase 9c,Caspase-9 subunit p10,ICE LAP6,ICE like apoptotic protease 6,ICE-like apoptotic protease 6,protein phosphatase 1,regulatory subunit 56,RNCASP9,MCH,Apoptotic protease Mch,PPP1R,ICE-LAP,CASP9,APAF-3,APAF3,ICE-LAP6,MCH6,PPP1R56,caspase-9,Caspase 9,CASP-9,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3 (APAF-3),ICE-like apoptotic protease 6 (ICE-LAP6),Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

Molecular Weight:

Calculated MW: 46 kDa

ObservedMW: 35 kDa,47 kDa

UniProt: P55211

Pathways: MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity