Recombinant GRK2 antibody

Catalog No. ABIN7828004

The Rabbit Monoclonal anti-GRK2 antibody is suitable to detect GRK2 in samples from Human, Mouse and Rat. It has been validated for WB and IF.

Quick Overview for Recombinant GRK2 antibody (ABIN7828004)

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GRK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: A240

Product Details anti-GRK2 Antibody

Purpose: Recombinant GRK2 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human GRK2 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000-1:5000,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for GRK2

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Alternative Name: GRK2

Background: GRK,Adrenergic beta receptor kinase,Beta adrenergic receptor kinase,Beta-adrenergic receptor kinase,G protein coupled receptor kinase,G-protein coupled receptor kinase,ARBK,ADRBK,GRK2,ADRBK1,BARK1,BETA-ARK1,Adrenergic beta receptor kinase 1,ARBK1,Beta adrenergic receptor kinase 1,Beta ARK 1,Beta ARK1,Beta-adrenergic receptor kinase 1,Beta-ARK-1,FLJ16718,G protein coupled receptor kinase 2,G-protein coupled receptor kinase 2,BARK,Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 80 kDa

Observed MW: 80 kDa

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling